The Data No One's Talking About

More than 50 million Americans live with autoimmune diseases.

And roughly 4 out of 5 of them are women. That’s not a coincidence. That’s a pattern.

Studies show spikes in autoimmune disease risk during:

• Puberty

• Pregnancy

• Postpartum

• Perimenopause

Translation? Your hormonal shifts aren’t just mood swings—they’re immune system triggers. And yet most patients never have their cycle mapped, hormones tracked, or immune markers tied to life stage.

What’s billed as “random” is often just unmeasured.

You weren’t hard to figure out. They just never looked.

The Estrogen Effect

Medical News Today highlights this clearly:

Estrogen modulates immune response.

• It boosts immune activity at certain levels

• It can turn up inflammation

• It affects how autoimmune conditions flare or fade across your life

But here’s the catch:

Most autoimmune protocols don’t factor that in at all.

You’re getting the same treatment plan whether you’re cycling, postpartum, or in menopause. Which is wild—because your immune system doesn’t function the same way in those phases.

Imagine treating a sprained ankle the same as a broken leg—just because they’re both “pain.” That’s how autoimmune care has handled women for decades.

Hormones Aren't Footnotes. They're Frontlines.

Autoimmune symptoms flare during puberty, pregnancy, postpartum, and perimenopause.

That’s not random—that’s estrogen in motion.

Yet most specialists don’t even ask where you are in your cycle.

You get meds, not maps. Suppression, not strategy.

Hormones aren’t a side note. They’re the script. And your body deserves a provider who can read it.

"It's Probably Just Stress."

That’s the default diagnosis when your fatigue is crushing, your joints ache, your gut’s a mess, and your labs are “mostly fine.” Stress isn’t a fake cause—but it’s also not a full explanation. Especially when your immune system is literally mistaking your own tissue as the enemy.

You’re not sensitive. You’re inflamed.

You’re not dramatic. You’re dysregulated.

The Research Is Thin Because the Funding Is Thinner.

Most autoimmune research was built on male test subjects. Most clinical trials still overlook hormonal variation. So your flares get dismissed. Your hunches get ignored. And your care gets standardized when what you need is customized.

It’s not that no one understands your disease.

It’s that no one studied someone like you long enough.

You're Not Making It Up. You're Making It Through.

Women with autoimmune disease aren’t unreliable narrators. They’re narrators medicine never gave a mic to. At thrē, we believe you the first time. We track patterns. We test the hard stuff. We don’t stop until the plan makes sense in your body—not just on paper.

But whether you’re here with us or still in the waiting room elsewhere, know this:

The pain is real.

The fatigue is real.

The way you’ve been dismissed? That’s real too.

You’re not crazy. You’re overdue for better.